Author: Zehua Zeng; Zhi Luo; Hongwu Du
Title: Predictions for the binding domain and potential new drug targets of 2019-nCoV Document date: 2020_3_2
ID: fvig79k3_35
Snippet: Previous reports have suggested that the conformational transformation of CTD1 from bottom to top was a prerequisite for receptor binding 13 , and that the spike protein of 2019-nCoV should also be trimer. A switch with more than one "up" CTD1 conformation will result in cleavage of the S1-ACE2 complex. Therefore, the research on new pneumonia drugs can also start from how to make spike trimer to turn on the upward switch. Antibodies against ACE2.....
Document: Previous reports have suggested that the conformational transformation of CTD1 from bottom to top was a prerequisite for receptor binding 13 , and that the spike protein of 2019-nCoV should also be trimer. A switch with more than one "up" CTD1 conformation will result in cleavage of the S1-ACE2 complex. Therefore, the research on new pneumonia drugs can also start from how to make spike trimer to turn on the upward switch. Antibodies against ACE2 or any compound that can bind to ACE2 are expected to be used in 2019-nCoV therapy, and the recognition of receptor binding sites will also contribute to the development of 2019-nCoV vaccine.
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