Author: Iwanski, Jessika; Kazmouz, Sobhi G.; Li, Shuaizhi; Stansfield, Ben; Salem, Tori T.; Perez-Miller, Samantha; Kazui, Toshinobu; Jena, Lipsa; Uhrlaub, Jennifer L.; Lick, Scott; Nikolich-Žugich, Janko; Konhilas, John P.; Gregorio, Carol C.; Khanna, May; Campos, Samuel K.; Churko, Jared M.
Title: Antihypertensive drug treatment and susceptibility to SARS-CoV-2 infection in human PSC-derived cardiomyocytes and primary endothelial cells Cord-id: kw7oduka Document date: 2021_9_1
ID: kw7oduka
Snippet: The pathogenicity of SARS-CoV-2 has been attributed to its ability to enter through the membrane-bound angiotensin-converting enzyme 2 (ACE2) receptor. Therefore, it has been heavily speculated that angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) therapy may modulate SARS-CoV-2 infection. In this study, exposure of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) and primary endothelial cells (hECs) to SARS-CoV-2 identified significant difference
Document: The pathogenicity of SARS-CoV-2 has been attributed to its ability to enter through the membrane-bound angiotensin-converting enzyme 2 (ACE2) receptor. Therefore, it has been heavily speculated that angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) therapy may modulate SARS-CoV-2 infection. In this study, exposure of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) and primary endothelial cells (hECs) to SARS-CoV-2 identified significant differences in protein coding genes involved in immunity, viral response, and cardiomyocyte/endothelial structure. Specifically, transcriptome changes were identified in the TNF, Interferon α/β, and MAPK (hPSC-CMs) as well as NF-kappaB (hECs) signalling pathways. However, pre-treatment of hPSC-CMs or hECs with two widely prescribed antihypertensive medications, losartan and lisinopril, did not affect the susceptibility of either cell type to SARS-CoV-2 infection. These findings demonstrate the toxic effects of SARS-CoV-2 in hPSC-CMs/hECs and taken together with newly emerging multicenter trials, suggest that antihypertensive drug treatment alone does not alter SARS-CoV-2 infection.
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