Author: Paul A. Rowley; Brandon Ho; Sarah Bushong; Arlen Johnson; Sara L. Sawyer
Title: XRN1 is a Species-Specific Virus Restriction Factor in Yeasts Document date: 2016_8_16
ID: 1znuxoj5_31
Snippet: Xrn1p was expressed at the lowest levels ( Fig 7D) . This is in contrast to XRN1 from S. 520 mikatae (n = 9) and S. bayanus (n = 8) that only showed a 13% increase or 15% 521 decrease in SkV-L-A1 RNAs, respectively. S. cerevisiae XRN1 was able to reduce SkV-522 L-A1 RNAs by 27% and is noteworthy due to the close evolutionary relationship between 523 SkV-L-A1 and other L-A-like viruses from S. cerevisiae ( Fig S6) . These data suggest 524 that Xrn.....
Document: Xrn1p was expressed at the lowest levels ( Fig 7D) . This is in contrast to XRN1 from S. 520 mikatae (n = 9) and S. bayanus (n = 8) that only showed a 13% increase or 15% 521 decrease in SkV-L-A1 RNAs, respectively. S. cerevisiae XRN1 was able to reduce SkV-522 L-A1 RNAs by 27% and is noteworthy due to the close evolutionary relationship between 523 SkV-L-A1 and other L-A-like viruses from S. cerevisiae ( Fig S6) . These data suggest 524 that Xrn1p is a species-specific restriction factor in different Saccharomyces yeasts, and 525 that coevolution of totiviruses and yeasts has specifically tailored the potency of Xrn1p to 526 control the replication of resident viruses within the same species. 527 528 All rights reserved. No reuse allowed without permission.
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