Author: Jones, Emma L; Gauge, Nathan; Nilsen, Odd Bjarte; Lowery, David; Wesnes, Keith; Katsaiti, Eirini; Arden, James; Amoako, Derek; Prophet, Nicholas; Purushothaman, Balaji; Green, David; Ballard, Clive
Title: Analysis of neuron-specific enolase and S100B as biomarkers of cognitive decline following surgery in older people. Cord-id: a36yvuhp Document date: 2012_1_1
ID: a36yvuhp
Snippet: BACKGROUND/AIMS Post-operative cognitive decline is frequent in older individuals following major surgery; however, biomarkers of this decline are less clearly defined. METHODS Sixty-eight participants over the age of 60 provided blood samples at baseline and 24 h post-surgery. Cognitive decline was measured at baseline and 52 weeks post-surgery using the Cambridge Assessment for Mental Disorder in the Elderly, section B (CAMCOG) score. Plasma levels of neuron-specific enolase (NSE) and S100B we
Document: BACKGROUND/AIMS Post-operative cognitive decline is frequent in older individuals following major surgery; however, biomarkers of this decline are less clearly defined. METHODS Sixty-eight participants over the age of 60 provided blood samples at baseline and 24 h post-surgery. Cognitive decline was measured at baseline and 52 weeks post-surgery using the Cambridge Assessment for Mental Disorder in the Elderly, section B (CAMCOG) score. Plasma levels of neuron-specific enolase (NSE) and S100B were measured by ELISA. RESULTS Baseline NSE and the change in NSE levels between baseline and 24 h were correlated with the change in CAMCOG score between baseline and 52 weeks. CONCLUSION NSE concentrations may be a useful predictor of individuals at risk of more severe long-term cognitive decline.
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