Vapor H2O2 sterilization as a decontamination method for the reuse of N95 respirators in the COVID-19 emergency

Ebru Oral; Keith K Wannomae; Rachel L Connolly; Joseph A Gardecki; Hui Min Leung; Orhun K Muratoglu; Anthony Griffiths; Anna N Honko; Laura E Avena; Lindsay GA McKay; Nick Flynn; Nadia Storm; Sierra N Downs; Ralph Jones; Brandon Emmal

is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.04.11.20062026 doi: medRxiv preprint 10.0 ± 0.6 (9.27 -10.53) Pass (4/4) SARS CoV-2 inactivation on face masks: VHP treatment of respirators intentionally contaminated with SARS-CoV-2 reduced the infectious virus load to below the limit of detection (1.3 log 10 , which is calculated based on the volumes of eluate used in the experiments and the premise that 1 PFU could be detected by the assays; Table 3 and Figure 1 ). There were no plaque forming units for samples treated with VHP. This corresponded to >3.8 log 10 reduction in infectious virus load compared to the virus stock and a >2.6 log 10 reduction compared to the infectious virus load on the respirators. . CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.