Author: McNaughton, Anna L.; D’Arienzo, Valentina; Ansari, M. Azim; Lumley, Sheila F.; Littlejohn, Margaret; Revill, Peter; McKeating, Jane A.; Matthews, Philippa C.
Title: Insights From Deep Sequencing of the HBV Genome—Unique, Tiny, and Misunderstood Cord-id: a75s0ip3 Document date: 2019_1_25
ID: a75s0ip3
Snippet: Hepatitis B virus (HBV) is a unique, tiny, partially double-stranded, reverse-transcribing DNA virus with proteins encoded by multiple overlapping reading frames. The substitution rate is surprisingly high for a DNA virus, but lower than that of other reverse transcribing organisms. More than 260 million people worldwide have chronic HBV infection, which causes 0.8 million deaths a year. Because of the high burden of disease, international health agencies have set the goal of eliminating HBV inf
Document: Hepatitis B virus (HBV) is a unique, tiny, partially double-stranded, reverse-transcribing DNA virus with proteins encoded by multiple overlapping reading frames. The substitution rate is surprisingly high for a DNA virus, but lower than that of other reverse transcribing organisms. More than 260 million people worldwide have chronic HBV infection, which causes 0.8 million deaths a year. Because of the high burden of disease, international health agencies have set the goal of eliminating HBV infection by 2030. Nonetheless, the intriguing HBV genome has not been well characterized. We summarize data on the HBV genome structure and replication cycle, explain and quantify diversity within and among infected individuals, and discuss advances that can be offered by application of next-generation sequencing technology. In-depth HBV genome analyses could increase our understanding of disease pathogenesis and allow us to better predict patient outcomes, optimize treatment, and develop new therapeutics.
Search related documents:
Co phrase search for related documents- acute liver failure and liver damage: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
- acute liver failure and liver disease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute liver failure and liver disease lead cause: 1
- acute liver failure and liver disease progression: 1, 2, 3
- acute liver failure and liver disease progression risk: 1
- acute liver failure and liver failure: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute liver failure and liver inflammation: 1, 2, 3, 4, 5, 6
- liver cancer and long association: 1
- liver cancer and long duration: 1
- liver cancer and long medium: 1
- liver cancer and long read sequencing: 1, 2
- liver damage and long period: 1, 2
- liver disease and long period: 1, 2
- liver failure and long association: 1
Co phrase search for related documents, hyperlinks ordered by date