Author: Turner, Malcolm
Title: Discovering the Role of Mannose-Binding Lectin (MBL) in Innate Immunity: The Early History Cord-id: a0hh7xic Document date: 2021_3_13
ID: a0hh7xic
Snippet: The so-called lectin pathway of complement activation was the third such molecular sequence to be described which results in enzymatic cleavage of the C3 component of complement. However its discovery was a gradual process arising from observations in different areas of the biological sciences. Three such strands of research predominated and these were pursued essentially independently of each other with little or no “cross talk†until 1989 when links began to be established. These areas of
Document: The so-called lectin pathway of complement activation was the third such molecular sequence to be described which results in enzymatic cleavage of the C3 component of complement. However its discovery was a gradual process arising from observations in different areas of the biological sciences. Three such strands of research predominated and these were pursued essentially independently of each other with little or no “cross talk†until 1989 when links began to be established. These areas of study were (1) Biochemical studies (especially in the field of liver biochemistry); (2) Identification of an immunodeficiency disorder and (3) Microbiology research.
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