Author: Rohan Maddamsetti; Daniel T. Johnson; Stephanie J. Spielman; Katherine L. Petrie; Debora S. Marks; Justin R. Meyer
Title: Viral gain-of-function experiments uncover residues under diversifying selection in nature Document date: 2018_1_3
ID: gqhlw20n_26
Snippet: For all non-parametric bootstrap calculations, we used 100,000 bootstraps, and chose groups of sites without replacement. For example, when testing for high entropy in the 17 MAGE residues, we generated an empirical null distribution by randomly choosing 17 different residues for one sample, and resampling 100,000 times. We used the same procedure for our evolutionary-rate tests. The copyright holder for this preprint (which was not peer-reviewed.....
Document: For all non-parametric bootstrap calculations, we used 100,000 bootstraps, and chose groups of sites without replacement. For example, when testing for high entropy in the 17 MAGE residues, we generated an empirical null distribution by randomly choosing 17 different residues for one sample, and resampling 100,000 times. We used the same procedure for our evolutionary-rate tests. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/242495 doi: bioRxiv preprint Amino acid and nucleotide changes are indicated by positions bookended by the wild-type state and then the evolved state. Amino acids in position 997 and 1107 have multiple derived states.
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