Author: Ni, Shuaijian; Yao, Houzong; Wang, Lili; Lu, Jun; Jiang, Feng; Lu, Aiping; Zhang, Ge
Title: Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes Cord-id: 61yo18q2 Document date: 2017_8_2
ID: 61yo18q2
Snippet: Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their development as drug candidates for therapeutic applications. In this review, we will discuss methods to conquer these challenges and highlight recent developments of chemical modifications and technolog
Document: Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their development as drug candidates for therapeutic applications. In this review, we will discuss methods to conquer these challenges and highlight recent developments of chemical modifications and technological advances that may enable early aptamers to be translated into clinical therapeutics.
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