Author: Williams, Thomas L.; Colzani, Maria T.; Macrae, Robyn G.C.; Robinson, Emma L.; Bloor, Stuart; Greenwood, Edward J. D.; Zhan, Jun Ru; Strachan, Gregory; Kuc, Rhoda E.; Nyimanu, Duuamene; Maguire, Janet J.; Lehner, Paul J.; Sinha, Sanjay; Davenport, Anthony P.
Title: Human embryonic stem cell-derived cardiomyocytes express SARS-CoV-2 host entry proteins: screen to identify inhibitors of infection Cord-id: abn6f8od Document date: 2021_1_22
ID: abn6f8od
Snippet: Patients with cardiovascular comorbidities are more susceptible to severe infection with SARS-CoV-2, known to directly cause pathological damage to cardiovascular tissue. We outline a screening platform using human embryonic stem cell-derived cardiomyocytes, confirmed to express the protein machinery critical for SARS-CoV-2 infection, and a pseudotyped virus system. The method has allowed us to identify benztropine and DX600 as novel inhibitors of SARS-CoV-2 infection.
Document: Patients with cardiovascular comorbidities are more susceptible to severe infection with SARS-CoV-2, known to directly cause pathological damage to cardiovascular tissue. We outline a screening platform using human embryonic stem cell-derived cardiomyocytes, confirmed to express the protein machinery critical for SARS-CoV-2 infection, and a pseudotyped virus system. The method has allowed us to identify benztropine and DX600 as novel inhibitors of SARS-CoV-2 infection.
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