Selected article for: "group comparison and significant difference"
Author: Yasunori Watanabe; Zachary T. Berndsen; Jayna Raghwani; Gemma E. Seabright; Joel D. Allen; Jason S. McLellan; Ian A. Wilson; Thomas A. Bowden; Andrew B. Ward; Max Crispin
Title: Vulnerabilities in coronavirus glycan shields despite extensive glycosylation
  • Document date: 2020_2_21
    • ID: bnnt05fn_11
    Snippet: Interestingly, SARS and HKU1 (SI Fig. 2 ) S proteins did not exhibit a specific mannose cluster that contributes to the overall mannose abundance, but rather only isolated glycans were underprocessed. We would speculate that the oligomannose-type glycans here arise from protein-directed inhibition of glycan processing, as opposed to the glycan-influenced processing observed on MERS. The presence of oligomannose-type glycans has also been implicat.....
    Document: Interestingly, SARS and HKU1 (SI Fig. 2 ) S proteins did not exhibit a specific mannose cluster that contributes to the overall mannose abundance, but rather only isolated glycans were underprocessed. We would speculate that the oligomannose-type glycans here arise from protein-directed inhibition of glycan processing, as opposed to the glycan-influenced processing observed on MERS. The presence of oligomannose-type glycans has also been implicated in innate immune recognition of coronaviruses by lectins 47,48 that recognise these underprocessed glycans as pathogen-associated molecular patterns.

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