Author: Di Paola, Nicholas; Sanchez-Lockhart, Mariano; Zeng, Xiankun; Kuhn, Jens H.; Palacios, Gustavo
Title: Viral genomics in Ebola virus research Cord-id: btaxvmsr Document date: 2020_5_4
ID: btaxvmsr
Snippet: Filoviruses such as Ebola virus continue to pose a substantial health risk to humans. Advances in the sequencing and functional characterization of both pathogen and host genomes have provided a wealth of knowledge to clinicians, epidemiologists and public health responders during outbreaks of high-consequence viral disease. Here, we describe how genomics has been historically used to investigate Ebola virus disease outbreaks and how new technologies allow for rapid, large-scale data generation
Document: Filoviruses such as Ebola virus continue to pose a substantial health risk to humans. Advances in the sequencing and functional characterization of both pathogen and host genomes have provided a wealth of knowledge to clinicians, epidemiologists and public health responders during outbreaks of high-consequence viral disease. Here, we describe how genomics has been historically used to investigate Ebola virus disease outbreaks and how new technologies allow for rapid, large-scale data generation at the point of care. We highlight how genomics extends beyond consensus-level sequencing of the virus to include intra-host viral transcriptomics and the characterization of host responses in acute and persistently infected patients. Similar genomics techniques can also be applied to the characterization of non-human primate animal models and to known natural reservoirs of filoviruses, and metagenomic sequencing can be the key to the discovery of novel filoviruses. Finally, we outline the importance of reverse genetics systems that can swiftly characterize filoviruses as soon as their genome sequences are available.
Search related documents:
Co phrase search for related documents- acute infection and adaptive innate intrinsic: 1
- acute infection and liver blood: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- acute infection and local clinician: 1
- acute infection and local staff: 1
- acute infection and long term effect: 1, 2, 3
- acute infection and low genetic diversity: 1
- acute infection and low number: 1, 2, 3, 4, 5, 6, 7, 8, 9
- acute infection and low resource: 1, 2, 3, 4
- acute infection and low sequence: 1
- acute infection and mabs binding: 1
- acute infection and mabs monoclonal antibody: 1
- acute infection and macaca fascicularis: 1, 2, 3, 4, 5, 6
- acute infection and macaca mulatta: 1, 2, 3, 4, 5, 6, 7, 8
- acute infection and macrophage monocyte: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- acute infection and macrophage monocyte cell: 1
- acute phase and adaptive innate: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- acute phase and liver blood: 1, 2, 3, 4, 5, 6, 7, 8, 9
- acute phase and local staff: 1
- acute phase and long term effect: 1, 2
Co phrase search for related documents, hyperlinks ordered by date