Author: Devaux, Christian A.; Lagier, Jean-Christophe; Raoult, Didier
Title: New Insights Into the Physiopathology of COVID-19: SARS-CoV-2-Associated Gastrointestinal Illness Cord-id: ln03g76f Document date: 2021_2_18
ID: ln03g76f
Snippet: Although SARS-CoV-2 is considered a lung-tropic virus that infects the respiratory tract through binding to the ACE2 cell-surface molecules present on alveolar lungs epithelial cells, gastrointestinal symptoms have been frequently reported in COVID-19 patients. What can be considered an apparent paradox is that these symptoms (e.g., diarrhea), sometimes precede the development of respiratory tract illness as if the breathing apparatus was not its first target during viral dissemination. Recently
Document: Although SARS-CoV-2 is considered a lung-tropic virus that infects the respiratory tract through binding to the ACE2 cell-surface molecules present on alveolar lungs epithelial cells, gastrointestinal symptoms have been frequently reported in COVID-19 patients. What can be considered an apparent paradox is that these symptoms (e.g., diarrhea), sometimes precede the development of respiratory tract illness as if the breathing apparatus was not its first target during viral dissemination. Recently, evidence was reported that the gut is an active site of replication for SARS-CoV-2. This replication mainly occurs in mature enterocytes expressing the ACE2 viral receptor and TMPRSS4 protease. In this review we question how SARS-CoV-2 can cause intestinal disturbances, whether there are pneumocyte-tropic, enterocyte-tropic and/or dual tropic strains of SARS-CoV-2. We examine two major models: first, that of a virus directly causing damage locally (e.g., by inducing apoptosis of infected enterocytes); secondly, that of indirect effect of the virus (e.g., by inducing changes in the composition of the gut microbiota followed by the induction of an inflammatory process), and suggest that both situations probably occur simultaneously in COVID-19 patients. We eventually discuss the consequences of the virus replication in brush border of intestine on long-distance damages affecting other tissues/organs, particularly lungs.
Search related documents:
Co phrase search for related documents- abdominal pain and acute ards respiratory distress syndrome: 1, 2, 3, 4
- abdominal pain and live virus: 1
- abdominal pain and lung damage: 1
- abdominal pain and lung heart: 1, 2
- abdominal pain and lung infection: 1, 2, 3, 4
- abdominal pain and lung microbiota: 1, 2, 3, 4
- abdominal pain and lung tissue: 1, 2
- abdominal pain and lymphocyte cell: 1, 2
- abdominal pain and lymphocyte count: 1, 2, 3, 4, 5, 6, 7, 8, 9
- abdominal pain and machine learning: 1
- abdominal pain nausea and acute ards respiratory distress syndrome: 1
- abdominal pain nausea and live virus: 1
- abdominal pain nausea and lung heart: 1
- abdominal pain nausea and lung infection: 1, 2
- abdominal pain nausea and lung microbiota: 1, 2, 3
- abdominal pain nausea and lung tissue: 1
- abdominal pain nausea and lymphocyte cell: 1, 2
- abdominal pain nausea and lymphocyte count: 1, 2, 3, 4
Co phrase search for related documents, hyperlinks ordered by date