Selected article for: "IFN receptor and type induction"
Author: CHEN, Yujuan; LIN, Junhong; ZHAO, Yao; MA, Xianping; YI, Huashan
Title: Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses
  • Cord-id: c40tidli
  • Document date: 2021_8_15
    • ID: c40tidli
    Snippet: Toll-like receptor 3 (TLR3) is a member of the TLR family, mediating the transcriptional induction of type I interferons (IFNs), proinflammatory cytokines, and chemokines, thereby collectively establishing an antiviral host response. Studies have shown that unlike other TLR family members, TLR3 is the only RNA sensor that is utterly dependent on the Toll-interleukin-1 receptor (TIR)‍-domain-containing adaptor-inducing IFN-‍β (TRIF). However, the details of how the TLR3-TRIF signaling pathwa
    Document: Toll-like receptor 3 (TLR3) is a member of the TLR family, mediating the transcriptional induction of type I interferons (IFNs), proinflammatory cytokines, and chemokines, thereby collectively establishing an antiviral host response. Studies have shown that unlike other TLR family members, TLR3 is the only RNA sensor that is utterly dependent on the Toll-interleukin-1 receptor (TIR)‍-domain-containing adaptor-inducing IFN-‍β (TRIF). However, the details of how the TLR3-TRIF signaling pathway works in an antiviral response and how it is regulated are unclear. In this review, we focus on recent advances in understanding the antiviral mechanism of the TRIF pathway and describe the essential characteristics of TLR3 and its antiviral effects. Advancing our understanding of TLR3 may contribute to disease diagnosis and could foster the development of novel treatments for viral diseases.

    Search related documents:
    Co phrase search for related documents
    • acid inducible and activation tbk1: 1
    • acid inducible and activator protein: 1, 2, 3
    • acid inducible and adaptive immunity: 1, 2
    • acid inducible gene and activation phosphorylation: 1, 2
    • acid inducible gene and activation tbk1: 1
    • acid inducible gene and activator protein: 1, 2, 3
    • acid inducible gene and adaptive immunity: 1, 2
    • activation phosphorylation and acute ards respiratory distress syndrome: 1
    • activation phosphorylation and adaptive immunity: 1
    • activation phosphorylation and adaptor act: 1
    • activation phosphorylation and adaptor act protein: 1
    • activation tbk1 and adaptor act: 1
    • activation tbk1 and adaptor act protein: 1
    • activator protein and acute ards respiratory distress syndrome: 1, 2, 3, 4, 5, 6
    • activator protein and adaptive immunity: 1
    • active phase and acute ards respiratory distress syndrome: 1
    • active phase and adaptive immunity: 1, 2
    • active research and acute ards respiratory distress syndrome: 1, 2, 3
    • active research and adaptive immunity: 1