Author: Ghazavi, Ali; Ganji, Ali; Keshavarzian, Nafiseh; Rabiemajd, Somayeh; Mosayebi, Ghasem
Title: Cytokine Profile and Disease Severity in Patients with COVID-19 Cord-id: c47z2o1f Document date: 2020_9_30
ID: c47z2o1f
Snippet: Cytokine dysregulation is the proposed mechanism for Coronavirus disease 2019 (COVID-19).The aim of this study was to evaluate the serum levels of interferon (IFN)-γ, interleukin (IL)-5, IL-8, Il-9, IL-17, TGF-β and IFN-γ in patients infected with SARS-CoV-2. The study was conducted between 63 adult patients with COVIDâ€19 and compared with 33 age and gender-matched healthy subjects as controls. The age range in both groups was 50 to 70 years. The patients were classified into mild group (33
Document: Cytokine dysregulation is the proposed mechanism for Coronavirus disease 2019 (COVID-19).The aim of this study was to evaluate the serum levels of interferon (IFN)-γ, interleukin (IL)-5, IL-8, Il-9, IL-17, TGF-β and IFN-γ in patients infected with SARS-CoV-2. The study was conducted between 63 adult patients with COVIDâ€19 and compared with 33 age and gender-matched healthy subjects as controls. The age range in both groups was 50 to 70 years. The patients were classified into mild group (33 patients) and severe group (30 patients). Serum samples were collected from all participants and tested for the cytokine levels by ELISA (enzyme-linked immunosorbent assay) method. Statistical analysis was performed using the one-way ANOVA. The mean serum levels of IFN-γ, TGF-β, IL-17 and IL-8 in the COVIDâ€19 patients were significantly higher than those observed in the control group. A comparison of between the mild and severe groups showed significant differences in TGF-β levels. The mean concentration of serum IL-5 and IL-9 in patients with COVIDâ€19 did not differ from those in the control group. Systemic IL-17 levels correlated positively and significantly with TGF-β in patients with COVIDâ€19. Th1 (IFN-γ), Treg (TGF-β), and Th17 (IL-17) cytokines concentration were increased in COVID-19 patients. Interferon-γ and IL-17 are involved in inducing and mediating proinflammatory responses. Our data suggest that TGF-β can be used as a predictive factor of disease severity in patients with COVID-19.
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