Author: MS Zinter; CC Dvorak; MY Mayday; K Iwanaga; NP Ly; ME McGarry; GD Church; LE Faricy; CM Rowan; JR Hume; ME Steiner; ED Crawford; C Langelier; K Kalantar; ED Chow; S Miller; K Shimano; A Melton; GA Yanik; A Sapru; JL DeRisi
Title: Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children Document date: 2018_3_29
ID: 28nlawnb_38
Snippet: Additional larger studies aimed at quantifying pulmonary microbial communities in immunocompromised children will naturally improve the value of Z-score analysis. Second, as with all mNGS assays, the identification of microbial nucleic acid does not directly confirm the presence of viable, live organisms, does not directly implicate that microbe as a contributor to pulmonary disease, and does not exclude less abundant organisms as potential contr.....
Document: Additional larger studies aimed at quantifying pulmonary microbial communities in immunocompromised children will naturally improve the value of Z-score analysis. Second, as with all mNGS assays, the identification of microbial nucleic acid does not directly confirm the presence of viable, live organisms, does not directly implicate that microbe as a contributor to pulmonary disease, and does not exclude less abundant organisms as potential contributors to pulmonary disease. In order to optimize patient outcomes, we advocate for ongoing multidisciplinary collaboration between intensivists, immunologists, oncologists, transplant physicians, infectious disease physicians, pulmonologists, bioinformaticians, and basic scientists. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/291864 doi: bioRxiv preprint
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