Author: Brufsky, Adam; Lotze, Michael T.
Title: DC/Lâ€SIGNs of Hope in the COVIDâ€19 Pandemic Cord-id: 430lrbyx Document date: 2020_5_6
ID: 430lrbyx
Snippet: In a rapidly evolving pandemic such as COVIDâ€19, theories which help unify disparate preâ€clinical and clinical observations would be useful. The current pandemic and its pleotropic effects can be explained in part by interaction between SARSâ€CoVâ€2 spike protein S, the ACE2/Lâ€SIGN/CD209 receptor on the type II alveolar cell of the lung, and the DCâ€SIGN receptor on the respiratory dendritic cell (DC) and associated endothelial cells. Infection of the DC by SARSâ€CoVâ€2 can potentiall
Document: In a rapidly evolving pandemic such as COVIDâ€19, theories which help unify disparate preâ€clinical and clinical observations would be useful. The current pandemic and its pleotropic effects can be explained in part by interaction between SARSâ€CoVâ€2 spike protein S, the ACE2/Lâ€SIGN/CD209 receptor on the type II alveolar cell of the lung, and the DCâ€SIGN receptor on the respiratory dendritic cell (DC) and associated endothelial cells. Infection of the DC by SARSâ€CoVâ€2 can potentially explain the exuberant distal immunopathology seen in COVIDâ€19. This article is protected by copyright. All rights reserved.
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