Selected article for: "dynamic range and log log"
Author: Xiaotian Tan; Cory Lin; Jie Zhang; Maung Kyaw Khaing Oo; Xudong Fan
Title: Rapid and quantitative detection of COVID-19 markers in micro-liter sized samples
  • Document date: 2020_4_22
    • ID: 0tdfvlqd_30
    Snippet: The entire dynamic ranges of these three antibodies against SARS-CoV-2 S1 can be found in Fig. S3 . The linear dynamic range in the log-log scale for CR3022, D001, and D006 are 7-500 ng/mL, 2-1000 ng/mL, and 2-1000 ng/mL. The corresponding slope in the linear range is 0.64, 0.83, and 0.81, respectively. As a negative control, a human IgG isotype does not generate any detectable signal within the entire range of detection (0.7-4800 ng/mL). Due to .....
    Document: The entire dynamic ranges of these three antibodies against SARS-CoV-2 S1 can be found in Fig. S3 . The linear dynamic range in the log-log scale for CR3022, D001, and D006 are 7-500 ng/mL, 2-1000 ng/mL, and 2-1000 ng/mL. The corresponding slope in the linear range is 0.64, 0.83, and 0.81, respectively. As a negative control, a human IgG isotype does not generate any detectable signal within the entire range of detection (0.7-4800 ng/mL). Due to the narrow linear dynamic range and relatively low binding affinity, CR3022 should not be used as the calibration standard of anti-SARS-CoV-2 S1 IgG. The remaining two antibodies, D001 and D006, are nearly the same in terms of the dynamic range and affinity towards SARS-CoV-2 S1. However, D006 has a better specificity for SARS-CoV-2 S1 compared to SARS-CoV S1. Therefore, D006 may be a better candidate as a calibration antibody. author/funder. All rights reserved. No reuse allowed without permission.

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