Author: Yafei Wang; Randy Heiland; Morgan Craig; Courtney L. Davis; Ashlee N Ford Versypt; Adrianne Jenner; Jonathan Ozik; Nicholson Collier; Chase Cockrell; Andrew Becker; Gary An; James A. Glazier; Aarthi Narayanan; Amber M Smith; Paul Macklin
Title: Rapid community-driven development of a SARS-CoV-2 tissue simulator Document date: 2020_4_5
ID: lq4tcyh4_148
Snippet: Running the overall model (with virus release turned on and off as appropriate for the respective unit tests) shows that the v1 prototype satisfies all the qualitative unit tests: a single cell is infected with a virion in the center of the tissue. Over time, the virion is uncoated to create functionalized RNA, which is synthesized to viral proteins and assembled to functional virus. The graphical output shows this center cell turning to a bright.....
Document: Running the overall model (with virus release turned on and off as appropriate for the respective unit tests) shows that the v1 prototype satisfies all the qualitative unit tests: a single cell is infected with a virion in the center of the tissue. Over time, the virion is uncoated to create functionalized RNA, which is synthesized to viral proteins and assembled to functional virus. The graphical output shows this center cell turning to a bright yellow as assembled virions accumulate. By enabling the substrate plot, we can see the diffusive field of virions first has zero concentration (no virions have been released), but as the first cell's viral production increases, it releases virus particles that begin diffusing into the domain. See Figure 3 (A).
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