Author: Yafei Wang; Randy Heiland; Morgan Craig; Courtney L. Davis; Ashlee N Ford Versypt; Adrianne Jenner; Jonathan Ozik; Nicholson Collier; Chase Cockrell; Andrew Becker; Gary An; James A. Glazier; Aarthi Narayanan; Amber M Smith; Paul Macklin
Title: Rapid community-driven development of a SARS-CoV-2 tissue simulator Document date: 2020_4_5
ID: lq4tcyh4_81
Snippet: Recently, agent-based models have been used to simulate viral propagation in 2-D tissues with simplified models of viral replication in individual cells, particularly in the field of influenza virus infection 76 a variety of other viral infections 77 , and oncolytic viral therapies [78] [79] [80] [81] . These models have generally not included detailed intracellular models of viral replication and individual cell responses to infection. However, .....
Document: Recently, agent-based models have been used to simulate viral propagation in 2-D tissues with simplified models of viral replication in individual cells, particularly in the field of influenza virus infection 76 a variety of other viral infections 77 , and oncolytic viral therapies [78] [79] [80] [81] . These models have generally not included detailed intracellular models of viral replication and individual cell responses to infection. However, they demonstrate the potential for including detailed intracellular models of viral replication in 2D and 3D tissues with the milieu of immune and epithelial cell types expected in actual patients, while also offering the opportunity to test hypotheses on the impact of viral mutagenicity and host cell heterogeneity on disease progression.
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