Author: James Bull; Scott L. Nuismer; Rustom Antia
Title: Recombinant vector vaccines and within-host evolution Document date: 2019_2_8
ID: 3vssgben_5
Snippet: The effect is biologically complicated because adaptive immunity to the antigen does not necessarily translate 190 into selection against the vaccine. Selection against the vaccine per se operates only when adaptive immunity 191 specifically targets the vaccine genome over the revertant genome, and this selection need not occur -either 192 because adaptive immunity is so delayed that it is never manifest during vaccine growth, or because the 193 .....
Document: The effect is biologically complicated because adaptive immunity to the antigen does not necessarily translate 190 into selection against the vaccine. Selection against the vaccine per se operates only when adaptive immunity 191 specifically targets the vaccine genome over the revertant genome, and this selection need not occur -either 192 because adaptive immunity is so delayed that it is never manifest during vaccine growth, or because the 193 antigen is physically decoupled from its genome when attacked by the adaptive response. Without imposing 194 selection on the vaccine, antigen-directed immunity will not affect vaccine evolution. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/545087 doi: bioRxiv preprint
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