Author: James Bull; Scott L. Nuismer; Rustom Antia
Title: Recombinant vector vaccines and within-host evolution Document date: 2019_2_8
ID: 3vssgben_6
Snippet: We now employ quantitative models to evaluate the intuitive ideas presented above. Given the high 197 dimensionality of the problem, we are especially interested in how well intuition works and whether generalities The models assist us by forcing us to specify assumptions for how the viruses and immunity interact, and 208 by allowing us to rigorously explore outcomes in different scenarios. However, there is uncertainty in the 209 model structure.....
Document: We now employ quantitative models to evaluate the intuitive ideas presented above. Given the high 197 dimensionality of the problem, we are especially interested in how well intuition works and whether generalities The models assist us by forcing us to specify assumptions for how the viruses and immunity interact, and 208 by allowing us to rigorously explore outcomes in different scenarios. However, there is uncertainty in the 209 model structure, many parameter values are unknown, and different viruses will behave somewhat differently.
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