Author: Juan Angel Patino-Galindo; Ioan Filip; Mohammed AlQuraishi; Raul Rabadan
Title: Recombination and lineage-specific mutations led to the emergence of SARS-CoV-2 Document date: 2020_2_18
ID: bgdcm1i1_2
Snippet: The capability of viral populations to emerge in new hosts can be explained by factors such as rapid mutation rates and recombination 6 which lead to both high genetic variability and high evolutionary rates (estimated to be between 10 -4 and 10 -3 substitutions per site per year) 7 . Previous genome-wide analyses in coronaviruses have estimated that their evolutionary rates are of the same order of magnitude as in other fast-evolving RNA viruses.....
Document: The capability of viral populations to emerge in new hosts can be explained by factors such as rapid mutation rates and recombination 6 which lead to both high genetic variability and high evolutionary rates (estimated to be between 10 -4 and 10 -3 substitutions per site per year) 7 . Previous genome-wide analyses in coronaviruses have estimated that their evolutionary rates are of the same order of magnitude as in other fast-evolving RNA viruses 8, 9 . Recombination in RNA viruses, known to be frequent in coronaviruses, can lead to the acquisition of genetic material from other viral strains 10 . Indeed, recombination has been proposed to play a major role in the generation of new coronavirus lineages such as SARS-CoV 10 .
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