Reduction of lymphocyte at early stage elevates severity and death risk of COVID-19 patients: a hospital-based case-cohort study

Jun Fei; Lin Fu; Ying Li; Hui-Xian Xiang; Ying Xiang; Meng-Die Li; Fang-Fang Liu; De-xiang Xu; Hui Zhao

lymphocyte. There was no difference in globulin and albumin/globulin ratio between two groups. Renal functions were also measured on admission among COVID-19 patients. As shown in Table 5 , creatinine and urea nitrogen were increased in patients with lymphocyte reduction. No significant difference on uric acid was observed between two groups. Moreover, myocardial function results suggested that creatine kinase, LDH, AST and AST/ALT ratio were significantly increased in patients with lymphocyte reduction compared with in patients with normal lymphocyte. The numbers of myoglobin-positive and cardiac troponin -positive patients with lymphocyte reduction were more than the patients with normal lymphocyte. The number of creatine kinase isoenzymes-positive patients were equal between two groups. Besides, respiratory function related biochemical indexes of COVID-19 patients were evaluated on admission. PaCO2, SpO2, oxygenation index were remarkably decreased in patients with lymphocyte reduction. In addition, we found that D-dimer and erythrocyte sedimentation rate were prominently increased in patients with lymphocyte reduction.