Selected article for: "correlation analysis and creatine kinase"
Author: Jun Fei; Lin Fu; Ying Li; Hui-Xian Xiang; Ying Xiang; Meng-Die Li; Fang-Fang Liu; De-xiang Xu; Hui Zhao
Title: Reduction of lymphocyte at early stage elevates severity and death risk of COVID-19 patients: a hospital-based case-cohort study
  • Document date: 2020_4_6
    • ID: 8q1veo3q_39
    Snippet: Previous studies found that multiple organ injures were prevalent in almost all COVID-19 patients, especially in critical ill cases (13) (14) (15) ). In the present research, we evaluated the severity of lung injury in COVID-19 patients using CT scores. We observed an obvious lung damage in almost all COVID-19 patients. Moreover, the CT scores were higher in COVID-19 patients with lymphocyte reduction than those in COVID-19 patients with normal l.....
    Document: Previous studies found that multiple organ injures were prevalent in almost all COVID-19 patients, especially in critical ill cases (13) (14) (15) ). In the present research, we evaluated the severity of lung injury in COVID-19 patients using CT scores. We observed an obvious lung damage in almost all COVID-19 patients. Moreover, the CT scores were higher in COVID-19 patients with lymphocyte reduction than those in COVID-19 patients with normal lymphocyte. Correlation analysis revealed that lymphocyte counts were negatively associated with CT scores. The association between lymphocyte reduction and respiratory function indices was then analyzed among COVID-19 patients. As expected, PaCO2, SpO2 and oxygenation index, several respiratory function markers, were decreased in COVID-19 patients with lymphocyte reduction. Next, the association between lymphocyte reduction and extrapulmonary organ injuries was analyzed among COVID-19 patients. We found that TBIL and DBIL, two markers of hepatic injury, creatinine and urea nitrogen, two indices of renal function, and creatine kinase, AST and LDH, three myocardial enzymes, were obviously elevated in COVID-19 patients with lymphocyte reduction.

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