Author: Avendaño-Ortiz, José; Lozano-RodrÃguez, Roberto; MartÃn-Quirós, Alejandro; Maroun-Eid, Charbel; Terrón, Verónica; ValentÃn, Jaime; Montalbán-Hernández, Karla; Ruiz de la Bastida, Fátima; GarcÃa-Garrido, Miguel A.; Cubillos-Zapata, Carolina; del Balzo-Castillo, Ãlvaro; Aguirre, Luis A.; López-Collazo, Eduardo
Title: Proteins from SARS-CoV-2 reduce T cell proliferation: a mirror image of sepsis Cord-id: cdkj8gc3 Document date: 2020_11_30
ID: cdkj8gc3
Snippet: Increased cytokine levels, acute phase reactants and immune checkpoint expression changes have been described in patients with Coronavirus Disease 2019 (COVID-19). Here, we have reported a monocyte polarization towards a low HLA-DR and high PD-L1 expression after long exposure to proteins from SARS-CoV-2. Moreover, CD86 expression was also reduced over SARS-CoV-2 proteins exposure. Additionally, T-cells proliferation was significantly reduced after stimulation with these proteins. Eventually, pa
Document: Increased cytokine levels, acute phase reactants and immune checkpoint expression changes have been described in patients with Coronavirus Disease 2019 (COVID-19). Here, we have reported a monocyte polarization towards a low HLA-DR and high PD-L1 expression after long exposure to proteins from SARS-CoV-2. Moreover, CD86 expression was also reduced over SARS-CoV-2 proteins exposure. Additionally, T-cells proliferation was significantly reduced after stimulation with these proteins. Eventually, patients with long-term SARS-CoV-2 infection also exhibited a significant blockade of T-cells proliferation.
Search related documents:
Co phrase search for related documents- accessory protein and acute respiratory infection: 1, 2, 3
- accessory protein and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48
- acute infection and adaptive immune system: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
- acute infection and adaptive response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40
- acute infection and adaptive system: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- acute infection and admission sars rt pcr positive: 1
- acute infection and long exposure: 1, 2, 3, 4, 5, 6, 7
- acute infection and long term patient: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- acute infection and lymphocyte count: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48
- acute infection and lymphocyte depletion: 1
- acute infection and lymphocyte expression: 1, 2, 3
- acute lymphopenia and lymphocyte count: 1, 2
Co phrase search for related documents, hyperlinks ordered by date