Author: Avendaño-Ortiz, José; Lozano-RodrÃguez, Roberto; MartÃn-Quirós, Alejandro; Maroun-Eid, Charbel; Terrón, Verónica; ValentÃn, Jaime; Montalbán-Hernández, Karla; Ruiz de la Bastida, Fátima; GarcÃa-Garrido, Miguel A.; Cubillos-Zapata, Carolina; del Balzo-Castillo, Ãlvaro; Aguirre, Luis A.; López-Collazo, Eduardo
Title: Proteins from SARS-CoV-2 reduce T cell proliferation: a mirror image of sepsis Cord-id: cdkj8gc3 Document date: 2020_11_30
ID: cdkj8gc3
Snippet: Increased cytokine levels, acute phase reactants and immune checkpoint expression changes have been described in patients with Coronavirus Disease 2019 (COVID-19). Here, we have reported a monocyte polarization towards a low HLA-DR and high PD-L1 expression after long exposure to proteins from SARS-CoV-2. Moreover, CD86 expression was also reduced over SARS-CoV-2 proteins exposure. Additionally, T-cells proliferation was significantly reduced after stimulation with these proteins. Eventually, pa
Document: Increased cytokine levels, acute phase reactants and immune checkpoint expression changes have been described in patients with Coronavirus Disease 2019 (COVID-19). Here, we have reported a monocyte polarization towards a low HLA-DR and high PD-L1 expression after long exposure to proteins from SARS-CoV-2. Moreover, CD86 expression was also reduced over SARS-CoV-2 proteins exposure. Additionally, T-cells proliferation was significantly reduced after stimulation with these proteins. Eventually, patients with long-term SARS-CoV-2 infection also exhibited a significant blockade of T-cells proliferation.
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