Author: Klumpp-Thomas, Carleen; Kalish, Heather; Hicks, Jennifer; Mehalko, Jennifer; Drew, Matthew; Memoli, Matthew J; Hall, Matthew D; Esposito, Dominic; Sadtler, Kaitlyn
Title: D614G Spike Variant Does Not Alter IgG, IgM, or IgA Spike Seroassay Performance Cord-id: clefny7s Document date: 2020_12_1
ID: clefny7s
Snippet: Emergence of a new spike protein variant (D614G) with increased infectivity has prompted many to analyze its role in the SARS-CoV-2 pandemic. There is concern regarding whether an individual exposed to one variant of a virus will have cross-reactive memory to the second. Accordingly, we analyzed the serologic reactivity of both variants, and found that antibodies from 88 donors from a high-incidence population reacted toward both the original spike and the D614 spike variant. These data suggest
Document: Emergence of a new spike protein variant (D614G) with increased infectivity has prompted many to analyze its role in the SARS-CoV-2 pandemic. There is concern regarding whether an individual exposed to one variant of a virus will have cross-reactive memory to the second. Accordingly, we analyzed the serologic reactivity of both variants, and found that antibodies from 88 donors from a high-incidence population reacted toward both the original spike and the D614 spike variant. These data suggest patients who are exposed to either variant have cross-responsive humoral immunity. This represents an important finding both for SARS-CoV-2 disease biology and for therapeutics.
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