Author: Mohammad Parohan; Sajad Yaghoubi; Asal Seraj; Mohammad Hassan Javanbakht; Payam Sarraf; Mahmoud Djalali
Title: Risk factors for mortality of adult inpatients with Coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis of retrospective studies Document date: 2020_4_11
ID: ih37onc3_22
Snippet: The other risk factors related to death include hypertension, diabetes, respiratory system disease 181 and CVDs. A previous study showed that hypertension and diabetes are more prevalent in patients 182 with severe MERS infection (22). Similarly, the mortality rate of influenza was significantly higher 183 in patients with hypertension, metabolic disease, CVDs and respiratory system disease (24). 184 Previous studies reported that high protein ex.....
Document: The other risk factors related to death include hypertension, diabetes, respiratory system disease 181 and CVDs. A previous study showed that hypertension and diabetes are more prevalent in patients 182 with severe MERS infection (22). Similarly, the mortality rate of influenza was significantly higher 183 in patients with hypertension, metabolic disease, CVDs and respiratory system disease (24). 184 Previous studies reported that high protein expression of angiotensin converting enzyme 2 (ACE2) 185 receptor, the receptor for COVID-19, in specific organs correlated with organ failures in SARS 186 patients (25-28). It has been shown that circulating ACE2 levels are higher in patients with 187 hypertension, diabetes and CVDs (29, 30). Therefore, patients with these comorbidities may be 188 more prone to die from COVID-19 infection because of the high expression of ACE2 receptor, 189 though further research on the mechanism is needed.
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