Selected article for: "RNA binding and scaffold RNA"
Author: Nila Roy Choudhury; Gregory Heikel; Maryia Trubitsyna; Peter Kubik; Jakub Stanislaw Nowak; Shaun Webb; Sander Granneman; Christos Spanos; Juri Rappsilber; Alfredo Castello; Gracjan Michlewski
Title: RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination
  • Document date: 2017_10_9
    • ID: ifla4aix_59
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. (Fig. 7) . In this context TRIM5 was shown to generate K63 ubiquitin chains, which are required for restriction of retroviral reverse transcription (Fletcher et al., 2015) . Thus, in the future, it will be important to assay other TRIM proteins to determine their RNA-binding activities. Notably, other E3 ubiquitin ligases, including Mex3b and Dizip3, have b.....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. (Fig. 7) . In this context TRIM5 was shown to generate K63 ubiquitin chains, which are required for restriction of retroviral reverse transcription (Fletcher et al., 2015) . Thus, in the future, it will be important to assay other TRIM proteins to determine their RNA-binding activities. Notably, other E3 ubiquitin ligases, including Mex3b and Dizip3, have been shown to use RNA as a scaffold to mediate the ubiquitination of their substrates, which are bound to the same RNA (Yoon et al., 2013) . Roquin is another example of an E3 ubiquitin ligase with a well-established RNA-binding ability (Leppek et al., 2013) . Moreover, the BRACA1 E3 ubiquitin ligase, which is implicated in familial breast cancer, has been shown to interact with RNAs (Kawai and Amano, 2012) . Altogether, these results strongly suggest the possibility of widespread roles of E3 ubiquitin ligases in the direct regulation of RNA metabolism.

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