Author: Chandrashekar, Abishek; Liu, Jinyan; Martinot, Amanda J.; McMahan, Katherine; Mercado, Noe B.; Peter, Lauren; Tostanoski, Lisa H.; Yu, Jingyou; Maliga, Zoltan; Nekorchuk, Michael; Busman-Sahay, Kathleen; Terry, Margaret; Wrijil, Linda M.; Ducat, Sarah; Martinez, David R.; Atyeo, Caroline; Fischinger, Stephanie; Burke, John S.; Slein, Matthew D.; Pessaint, Laurent; Van Ry, Alex; Greenhouse, Jack; Taylor, Tammy; Blade, Kelvin; Cook, Anthony; Finneyfrock, Brad; Brown, Renita; Teow, Elyse; Velasco, Jason; Zahn, Roland; Wegmann, Frank; Abbink, Peter; Bondzie, Esther A.; Dagotto, Gabriel; Gebre, Makda S.; He, Xuan; Jacob-Dolan, Catherine; Kordana, Nicole; Li, Zhenfeng; Lifton, Michelle A.; Mahrokhian, Shant H.; Maxfield, Lori F.; Nityanandam, Ramya; Nkolola, Joseph P.; Schmidt, Aaron G.; Miller, Andrew D.; Baric, Ralph S.; Alter, Galit; Sorger, Peter K.; Estes, Jacob D.; Andersen, Hanne; Lewis, Mark G.; Barouch, Dan H.
Title: SARS-CoV-2 infection protects against rechallenge in rhesus macaques Cord-id: car394ou Document date: 2020_5_20
ID: car394ou
Snippet: An understanding of protective immunity to SARS-CoV-2 is critical for vaccine and public health strategies aimed at ending the global COVID-19 pandemic. A key unanswered question is whether infection with SARS-CoV-2 results in protective immunity against re-exposure. We developed a rhesus macaque model of SARS-CoV-2 infection and observed that macaques had high viral loads in the upper and lower respiratory tract, humoral and cellular immune responses, and pathologic evidence of viral pneumonia.
Document: An understanding of protective immunity to SARS-CoV-2 is critical for vaccine and public health strategies aimed at ending the global COVID-19 pandemic. A key unanswered question is whether infection with SARS-CoV-2 results in protective immunity against re-exposure. We developed a rhesus macaque model of SARS-CoV-2 infection and observed that macaques had high viral loads in the upper and lower respiratory tract, humoral and cellular immune responses, and pathologic evidence of viral pneumonia. Following initial viral clearance, animals were rechallenged with SARS-CoV-2 and showed 5 log(10) reductions in median viral loads in bronchoalveolar lavage and nasal mucosa compared with primary infection. Anamnestic immune responses following rechallenge suggested that protection was mediated by immunologic control. These data show that SARS-CoV-2 infection induced protective immunity against re-exposure in nonhuman primates.
Search related documents:
Co phrase search for related documents- absence presence and additional research: 1
- absence presence and live virus: 1, 2
- absence presence and low response: 1, 2
- absence presence and lung parenchyma: 1
- absence presence and lung tissue: 1, 2, 3, 4, 5, 6, 7, 8
- absence presence and lung trachea: 1
- absence presence and lymph node: 1, 2, 3, 4, 5
- absence presence and macaque model: 1, 2
- acute inflammation and additional research: 1
- acute inflammation and lung parenchyma: 1, 2, 3, 4, 5
- acute inflammation and lung tissue: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
- acute inflammation and lymph node: 1, 2
- acute inflammation and macaque model: 1
- acute inflammation and macrophage marker: 1
- adcd antibody dependent complement deposition and adcp antibody dependent cellular phagocytosis: 1
- additional research and low response: 1
- additional research and lung parenchyma: 1
- additional research and lymph node: 1
- live virus and low respiratory tract: 1, 2
Co phrase search for related documents, hyperlinks ordered by date