Selected article for: "drug level and intracellular drug level"
Author: Krishan Mohan Kapoor; Aanandita Kapoor
Title: Role of Chloroquine and Hydroxychloroquine in the Treatment of COVID-19 Infection- A Systematic Literature Review
  • Document date: 2020_3_30
    • ID: 0lk8eujq_20
    Snippet: The data on the kinetics of chloroquine uptake indicated the drug attained near-maximum intracellular concentrations in 1 hr and a drug level of 60 μg/ml produced a decrement in the cellular biosynthesis of protein, RNA, or DNA. Herpes simplex replication was found to be sensitive to this drug as the level of progeny virus production was depressed by 95% in 24 hr. 32 CQ also affects viral replication by inhibiting viral gene expression. CQ has a.....
    Document: The data on the kinetics of chloroquine uptake indicated the drug attained near-maximum intracellular concentrations in 1 hr and a drug level of 60 μg/ml produced a decrement in the cellular biosynthesis of protein, RNA, or DNA. Herpes simplex replication was found to be sensitive to this drug as the level of progeny virus production was depressed by 95% in 24 hr. 32 CQ also affects viral replication by inhibiting viral gene expression. CQ has an ability to change the pattern of glycosylation in HIV-1 gp120 envelope during In vitro and in vivo tests. CQ also inhibits the replication of the HIV virus in CD4 + T cells 33 . Both CQ and HCQ are weakly alkaline bases and All rights reserved. No reuse allowed without permission.

    Search related documents:
    Co phrase search for related documents
    • cellular biosynthesis and Herpes simplex: 1
    • cellular biosynthesis and HIV virus: 1
    • cellular biosynthesis and viral gene expression: 1
    • DNA RNA protein and gene expression: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • DNA RNA protein and Herpes simplex: 1
    • DNA RNA protein and HIV virus: 1, 2
    • DNA RNA protein and viral gene expression: 1
    • drug level and gene expression: 1, 2, 3, 4
    • gene expression and glycosylation pattern: 1, 2
    • gene expression and Herpes simplex: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • gene expression and Herpes simplex replication: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • gene expression and HIV virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • gene expression and HIV virus replication: 1
    • gene expression and intracellular concentration: 1, 2, 3
    • gene expression and progeny virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
    • gene expression and progeny virus production: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • gene expression and viral gene expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • glycosylation pattern and Herpes simplex: 1
    • glycosylation pattern and HIV virus: 1, 2