Author: Cécilia Hognon; Tom Miclot; Cristina Garcia Iriepa; Antonio Francés-Monerris; Stephanie Grandemange; Alessio Terenzi; Marco Marazzi; Giampaolo Barone; Antonio Monari
Title: Role of RNA Guanine Quadruplexes in Favoring the Dimerization of SARS Unique Domain in Coronaviruses Document date: 2020_4_10
ID: dnppshnv_5
Snippet: Interestingly, the interaction is sufficiently strong to induce a partial deformation of the planarity of the G4 leaflets. The fact that the monomeric binding mode is driven by dispersion interactions with one of the exposed G4 leaflets may also contribute explaining the fact that longer G4 sequences are preferentially recognized by the SUD interface region. Indeed, in this case, for obvious statistic reasons, the ratio between electrostatic and .....
Document: Interestingly, the interaction is sufficiently strong to induce a partial deformation of the planarity of the G4 leaflets. The fact that the monomeric binding mode is driven by dispersion interactions with one of the exposed G4 leaflets may also contribute explaining the fact that longer G4 sequences are preferentially recognized by the SUD interface region. Indeed, in this case, for obvious statistic reasons, the ratio between electrostatic and dispersion interactions clearly favors the latter. On the other hand, this mode may also act efficiently in the process of recruitment of RNA, either viral or cellular, efficiently anchoring the oligomer that can subsequently be safely displaced through the interface area.
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