Older adults with SARS-CoV2 infection: Utility of the Clinical Frailty Scale to predict mortality.

Gilis, Marine; Chagrot, Ninon; Koeberle, Severine; Tannou, Thomas; Brunel, Anne-Sophie; Chirouze, Catherine; Bouiller, Kevin

OBJECTIVE The objective of this study was to identify predictive factors of mortality in older adults with COVID-19, including the level of clinical frailty by using the Clinical Frailty Scale (CFS). METHODS We analyzed medical records of all patients aged of 75 and older with a confirmed diagnosis of COVID-19 hospitalized in our Hospital between March 3, 2020 and April 25, 2020. Standardized variables were prospectively collected, and standardized care were provided to all patients. RESULTS 186 patients were included (mean 85.3±5.78 y). The all cause 30-day mortality was 30% (56/186). At admission, dead patients were more dyspneic (57% vs 38%, p=0.014), had more often an oxygen saturation <94% (70% vs 47%, p<0.01) and had more often a heart rate faster than 90/min (70% vs 42%, p<0.001). Mortality increased in parallel with CFS score (p=0.051) (20 deaths (36%) in 7-9 category). In multivariate analysis, CFS score (OR= 1.49 CI (95%), 1.01-2.19, p=0.046), age (OR=1.15 CI 95% 1.01-1.31 p=0.034), and dyspnea (OR=5.37 CI 95% 1.33-21.68, p=0.018) were associated with all-cause 30-day mortality. CONCLUSIONS It is necessary to integrate the assessment of frailty to determine care management plan of older patients with COVID-19, rather than the only restrictive criterion of age. This article is protected by copyright. All rights reserved.