Selected article for: "µg ml and neutralizing activity"
Author: Chunyun Sun; Long Chen; Ji Yang; Chunxia Luo; Yanjing Zhang; Jing Li; Jiahui Yang; Jie Zhang; Liangzhi Xie
Title: SARS-CoV-2 and SARS-CoV Spike-RBD Structure and Receptor Binding Comparison and Potential Implications on Neutralizing Antibody and Vaccine Development
  • Document date: 2020_2_20
    • ID: nhq0oq8y_22
    Snippet: SARS-CoV monoclonal nAbs with strong S1 binding (EC 50 <50ng/mL, K D ≤2.0E-10 M) and potent ACE2-blocking activities exhibited potent neutralizing activities against SARS-CoV (minimum dose to reach 100% neutralization at ~0.1μg/mL), but almost no cross-binding to SARS-CoV-2 S1 protein (EC 50 >15μg/mL) and no cross-neutralizing activities against SARS-CoV-2 PSV (<50% neutralizing activity at 100μg/mL) (Figure3, Table 2, Figure S1 & S2)......
    Document: SARS-CoV monoclonal nAbs with strong S1 binding (EC 50 <50ng/mL, K D ≤2.0E-10 M) and potent ACE2-blocking activities exhibited potent neutralizing activities against SARS-CoV (minimum dose to reach 100% neutralization at ~0.1μg/mL), but almost no cross-binding to SARS-CoV-2 S1 protein (EC 50 >15μg/mL) and no cross-neutralizing activities against SARS-CoV-2 PSV (<50% neutralizing activity at 100μg/mL) (Figure3, Table 2, Figure S1 & S2).

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