Author: Timokratis Karamitros; Gethsimani Papadopoulou; Maria Bousali; Anastasios Mexias; Sotiris Tsiodras; Andreas Mentis
Title: SARS-CoV-2 exhibits intra-host genomic plasticity and low-frequency polymorphic quasispecies Document date: 2020_3_28
ID: jxm69ndw_15
Snippet: Intra-host variants were distributed across 7 out of the 10 protein-coding genes of the viral genome, namely ORF1ab, S, ORF3a, ORF6, ORF7a, ORF8 and N. After normalising for the gene length (variants / kb-gene-length -"v/kbgl"), the higher density was observed in the small ORF6 (16.21 v/kbgl), followed by ORF8 (8.21 v/kbgl), N (4.76 v/kbgl), S (4.18 v/kbgl), ORF1ab (3.47 v/kbgl), ORF7a (2.73 v/kbgl) and ORF3a (1.21 v/kbgl). Interestingly, the maj.....
Document: Intra-host variants were distributed across 7 out of the 10 protein-coding genes of the viral genome, namely ORF1ab, S, ORF3a, ORF6, ORF7a, ORF8 and N. After normalising for the gene length (variants / kb-gene-length -"v/kbgl"), the higher density was observed in the small ORF6 (16.21 v/kbgl), followed by ORF8 (8.21 v/kbgl), N (4.76 v/kbgl), S (4.18 v/kbgl), ORF1ab (3.47 v/kbgl), ORF7a (2.73 v/kbgl) and ORF3a (1.21 v/kbgl). Interestingly, the majority of the SNPs corresponded to missense changes (leading to amino-acid change) compared to synonymous changes (72 vs. 29 respectively, ratio 2.48:1) ( Table 1) . The average intra-host variant frequency did not differ substantially either between missense and synonymous polymorphisms (Figure 1 .C), neither between their hosting genes (Figure 1
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