Author: Timokratis Karamitros; Gethsimani Papadopoulou; Maria Bousali; Anastasios Mexias; Sotiris Tsiodras; Andreas Mentis
Title: SARS-CoV-2 exhibits intra-host genomic plasticity and low-frequency polymorphic quasispecies Document date: 2020_3_28
ID: jxm69ndw_2
Snippet: Intra host variability of pathogenic viruses and bacteria represents a significant barrier in the control of infectious diseases. In viral infections, this variation emerges from genomic phenomena taking place during error-prone replication, ending up to multiple circulating quasispecies of low or higher frequency [10] , [11] . These variants, in combination with the genetic profile of the host, can potentially influence the natural history of th.....
Document: Intra host variability of pathogenic viruses and bacteria represents a significant barrier in the control of infectious diseases. In viral infections, this variation emerges from genomic phenomena taking place during error-prone replication, ending up to multiple circulating quasispecies of low or higher frequency [10] , [11] . These variants, in combination with the genetic profile of the host, can potentially influence the natural history of the infection, the viral phenotype, but also the sensitivity of molecular and serological diagnostics assays [12] , [13] .
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