Author: Gasparello, Jessica; d'Aversa, Elisabetta; Breveglieri, Giulia; Borgatti, Monica; Finotti, Alessia; Gambari, Roberto
Title: In vitro induction of interleukin-8 by SARS-CoV-2 Spike protein is inhibited in bronchial epithelial IB3-1 cells by a miR-93-5p agomiR Cord-id: cnqxzpr6 Document date: 2021_9_28
ID: cnqxzpr6
Snippet: One of the major clinical features of COVID-19 is a hyperinflammatory state, which is characterized by high expression of cytokines (such as IL-6, IL-8 and TNF-α), chemokines and growth factors and is associated with severe forms of COVID-19. For this reason, the control of the “cytokine storm†represents a key issue in the management of COVID-19 patients. In this study we report evidence that the release of key proteins of the COVID-19 “cytokine storm†can be inhibited by mimicking the
Document: One of the major clinical features of COVID-19 is a hyperinflammatory state, which is characterized by high expression of cytokines (such as IL-6, IL-8 and TNF-α), chemokines and growth factors and is associated with severe forms of COVID-19. For this reason, the control of the “cytokine storm†represents a key issue in the management of COVID-19 patients. In this study we report evidence that the release of key proteins of the COVID-19 “cytokine storm†can be inhibited by mimicking the biological activity of microRNAs. The major focus of this report is on IL-8, whose expression can be modified by the employment of a molecule mimicking miR-93-5p, which is able to target the IL-8 RNA transcript and modulate its activity. The results obtained demonstrate that the production of IL-8 protein is enhanced in bronchial epithelial IB3-1 cells and that IL-8 synthesis and extracellular release can be strongly reduced using an agomiR molecule mimicking miR-93-5p.
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