Author: Matthew S. Faber; James T. Van Leuven; Martina M. Ederer; Yesol Sapozhnikov; Zoë L. Wilson; Holly A. Wichman; Timothy A. Whitehead; Craig R. Miller
Title: Saturation mutagenesis genome engineering of infective FX174 bacteriophage via unamplified oligo pools and golden gate assembly Document date: 2019_10_9
ID: 02zzb7v1_5
Snippet: ΦX174 has also been extensively studied (Aoyama et al. 1981 , Hafenstein and Fane 2002 , Bernal et al. 2004 , Rokyta et al. 2006 , especially as a model system for experimental evolution (Bull et al. 1997 , Crill, Wichman, and Bull 2000 , Wichman, Millstein, and Bull 2005 since populations grow rapidly to very large size, mutation rate is high, and the fitness differences between even single mutations can be very large. One of the focal areas of.....
Document: ΦX174 has also been extensively studied (Aoyama et al. 1981 , Hafenstein and Fane 2002 , Bernal et al. 2004 , Rokyta et al. 2006 , especially as a model system for experimental evolution (Bull et al. 1997 , Crill, Wichman, and Bull 2000 , Wichman, Millstein, and Bull 2005 since populations grow rapidly to very large size, mutation rate is high, and the fitness differences between even single mutations can be very large. One of the focal areas of work on ΦX174 and related microvirid phage has been testing models of adaptive evolution and epistasis with empirical data (Rokyta et al. 2005 , Caudle, Miller, and Rokyta 2014 , Sackman and Rokyta 2018 . The inferential power of these studies has been limited by the modest sizes of the mutational libraries.
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