Author: Jacob Kames; David Dillon Holcomb; Ofer Kimchi; Michael DiCuccio; Nobuko Hamasaki-Katagiri; Tony Wang; Anton A Komar; Aikaterini Alexaki; Chava Kimchi-Sarfaty
Title: Sequence analysis of SARS-CoV-2 genome reveals features important for vaccine design Document date: 2020_3_31
ID: 2fn25l6m_23
Snippet: Furthermore, altering its RNA sequence is likely to disturb the pseudoknot that is responsible for frameshifting. Since we have identified the sequence that is responsible for the frameshift, a partial codon pair deoptimization is possible. However, ORF1ab is essential for genome replication, which also does not support its capacity as a codon deoptimization target......
Document: Furthermore, altering its RNA sequence is likely to disturb the pseudoknot that is responsible for frameshifting. Since we have identified the sequence that is responsible for the frameshift, a partial codon pair deoptimization is possible. However, ORF1ab is essential for genome replication, which also does not support its capacity as a codon deoptimization target.
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