Selected article for: "SARS entry and scrna seq"
Author: Allen Wang; Joshua A Chiou; Olivier B Poirion; Justin Buchanan; Michael J Valdez; Jamie M Verheyden; Xiaomeng Hou; Minzhe Guo; Jacklyn M Newsome; Parul Kudtarkar; Dina A Faddah; Kai Zhang; Randee E Young; Justinn Barr; Ravi Misra; Heidie Huyck; Lisa Rogers; Cory Poole; Jeffery A Whitsett; Gloria Pryhuber; Yan Xu; Kyle J Gaulton; Sebastian Preissl; Xin Sun
Title: Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection
  • Document date: 2020_4_14
    • ID: 5kvq6jtx_14
    Snippet: Tissue Core, which provided the frozen biopsies for this study, does not have donors 281 older than ~30. We therefore instead, identified 4 publicly available scRNA-seq datasets 282 from non-diseased lungs of ages >55 that served as controls in pulmonary fibrosis studies 283 Figure S4A ). Compared to 30yo samples, we observed a trend for 287 increased frequency of ACE2 + (p = 0.095) and TMPRSS2 + (p = 0.070) AT2 cells in 288 the >55yo group (Aged.....
    Document: Tissue Core, which provided the frozen biopsies for this study, does not have donors 281 older than ~30. We therefore instead, identified 4 publicly available scRNA-seq datasets 282 from non-diseased lungs of ages >55 that served as controls in pulmonary fibrosis studies 283 Figure S4A ). Compared to 30yo samples, we observed a trend for 287 increased frequency of ACE2 + (p = 0.095) and TMPRSS2 + (p = 0.070) AT2 cells in 288 the >55yo group (Aged; Figure S4B ). While these patterns are consistent with 289 epidemiological findings that elderly are at highest risk, we make these observations 290 cautiously due to the multiple potential confounding variables present when comparing 291 across independent datasets spanning multiple methodologies. 292 293 . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.12.037580 doi: bioRxiv preprint Annotation of cis-regulatory sequences linked to SARS-CoV-2 viral entry gene 294 activity 295

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