Author: Ryan M. Carey; Jenna R. Freund; Benjamin M. Hariri; Nithin D. Adappa; James N. Palmer; Robert J. Lee
Title: Altered polarization of PAR-2 signaling during airway epithelial remodeling Document date: 2020_1_9
ID: 8iet67u3_27
Snippet: Similar responses to apical 2FLI were observed after 21 days of differentiation + 4 days of submersion (Fig 4C) . Apical 2FLI response was blocked by PAR-2 antagonist FSLLRY-NH2 ( Fig 4C) . We performed experiments using cells from cystic fibrosis (CF) patients homozygous for DF508 CFTR. CF ALIs robustly secreted fluid in response to PAR-2 stimulation. These data suggest that apical PAR-2 agonist exposure does not result in epithelial fluid sec.....
Document: Similar responses to apical 2FLI were observed after 21 days of differentiation + 4 days of submersion (Fig 4C) . Apical 2FLI response was blocked by PAR-2 antagonist FSLLRY-NH2 ( Fig 4C) . We performed experiments using cells from cystic fibrosis (CF) patients homozygous for DF508 CFTR. CF ALIs robustly secreted fluid in response to PAR-2 stimulation. These data suggest that apical PAR-2 agonist exposure does not result in epithelial fluid secretion in well differentiated cultures, but remodeling or dedifferentiation results in apical PAR-2-activated fluid secretion via CaCC.
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