Author: Allen Wang; Joshua A Chiou; Olivier B Poirion; Justin Buchanan; Michael J Valdez; Jamie M Verheyden; Xiaomeng Hou; Minzhe Guo; Jacklyn M Newsome; Parul Kudtarkar; Dina A Faddah; Kai Zhang; Randee E Young; Justinn Barr; Ravi Misra; Heidie Huyck; Lisa Rogers; Cory Poole; Jeffery A Whitsett; Gloria Pryhuber; Yan Xu; Kyle J Gaulton; Sebastian Preissl; Xin Sun
Title: Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection Document date: 2020_4_14
ID: 5kvq6jtx_29
Snippet: Given that common AT2 variants showed predicted regulatory function and 424 association with respiratory disease and infection phenotypes, we next asked whether 425 these variants regulated the expression of TMPRSS2 using human lung eQTL data from 426 the GTEx v8 release. Among variants tested for association in GTEx, we observed a 427 highly significant eQTL for TMPRSS2 expression at rs35074065 (p=3.9×10 -11 ) as well as 428 more nominal eQTL e.....
Document: Given that common AT2 variants showed predicted regulatory function and 424 association with respiratory disease and infection phenotypes, we next asked whether 425 these variants regulated the expression of TMPRSS2 using human lung eQTL data from 426 the GTEx v8 release. Among variants tested for association in GTEx, we observed a 427 highly significant eQTL for TMPRSS2 expression at rs35074065 (p=3.9×10 -11 ) as well as 428 more nominal eQTL evidence at rs1557372 (p=2.9×10 -5 ) and rs9974995 (p=3.5×10 -6 ). 429
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