Selected article for: "SARS pathogen and viral protein"
Author: Jieyu Guo; Xiangxiang Wei; Qinhan Li; Liliang Li; Zhaohua Yang; Yu Shi; Yue Qin; Xinyue Zhang; Xinhong Wang; Xiuling Zhi; Dan Meng
Title: Single-cell RNA Analysis on ACE2 Expression Provides Insight into SARS-CoV-2 Blood Entry and Heart Injury
  • Document date: 2020_4_4
    • ID: in3b1nzv_1
    Snippet: COVID-19 is a global pandemic with high infectivity and pathogenicity, accounting for tens of thousands of deaths worldwide. The pathogen named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) showed 79.5% genome similarity to SARS-CoV and 96% to a bat coronavirus RaTG13 1 . Angiotensin converting enzyme II (ACE2) can specifically bind to the S1 domain of SARS-CoV S protein as a functional receptor 2 and is also the cellular receptor .....
    Document: COVID-19 is a global pandemic with high infectivity and pathogenicity, accounting for tens of thousands of deaths worldwide. The pathogen named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) showed 79.5% genome similarity to SARS-CoV and 96% to a bat coronavirus RaTG13 1 . Angiotensin converting enzyme II (ACE2) can specifically bind to the S1 domain of SARS-CoV S protein as a functional receptor 2 and is also the cellular receptor of SARS-CoV-2. ACE2 has been widely recognized as a negative regulatory enzyme of the renin-angiotensin system (RAS) that converts Ang II into Ang1-7 /Ang 1-9 and has a protective role in cardiovascular function 3 . Upon spike protein of coronavirus binding to the cellular receptor ACE2, the type II transmembrane serine protease (TTSP) TMPRSS2 cleaves the SARS-CoV-2 spike protein to promote fusion of viral and cellular membranes 4 .

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