Author: Sahu, Utkarsha; Biswas, Debasis; Prajapati, Vijay Kumar; Singh, Anirudh K.; Samant, Mukesh; Khare, Prashant
Title: Interleukinâ€17—A multifaceted cytokine in viral infections Cord-id: mzpld6do Document date: 2021_6_16
ID: mzpld6do
Snippet: Viral infections are a major threat to the human population due to the lack of selective therapeutic measures. The morbidity and mortality reported worldwide are very alarming against viral pathogens. The proinflammatory environment is required for viral inhibition by initiating the host immune response. The host immune response fights these pathogens by secreting different cytokines. Interleukinâ€17 (ILâ€17) a proinflammatory cytokine mainly produced by T helper type 17 cells, plays a vital r
Document: Viral infections are a major threat to the human population due to the lack of selective therapeutic measures. The morbidity and mortality reported worldwide are very alarming against viral pathogens. The proinflammatory environment is required for viral inhibition by initiating the host immune response. The host immune response fights these pathogens by secreting different cytokines. Interleukinâ€17 (ILâ€17) a proinflammatory cytokine mainly produced by T helper type 17 cells, plays a vital role in the regulation of host immune response against various pathogens, including viruses. However, dysregulated production of ILâ€17 induces chronic inflammation, autoimmune disorders, and may lead to cancer. Recent studies suggest that ILâ€17 is not only involved in the antiviral immune response but also promotes virusâ€mediated illnesses. In this review, we discuss the protective and pathogenic role of ILâ€17 against various viral infections. A detailed understanding of ILâ€17 during viral infections could contribute to improve therapeutic measures and enable the development of an efficient and safe ILâ€17 based immunotherapy.
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