Author: Connors, Jennifer; Bell, Matthew R.; Marcy, Jennifer; Kutzler, Michele; Haddad, Elias K.
Title: The impact of immuno-aging on SARS-CoV-2 vaccine development Cord-id: 6jfpbtbu Document date: 2021_2_11
ID: 6jfpbtbu
Snippet: The SARS-CoV-2 pandemic has almost 56 million confirmed cases resulting in over 1.3 million deaths as of November 2020. This infection has proved more deadly to older adults (those >65 years of age) and those with immunocompromising conditions. The worldwide population aged 65 years and older is increasing, and the total number of aged individuals will outnumber those younger than 65 years by the year 2050. Aging is associated with a decline in immune function and chronic activation of inflammat
Document: The SARS-CoV-2 pandemic has almost 56 million confirmed cases resulting in over 1.3 million deaths as of November 2020. This infection has proved more deadly to older adults (those >65 years of age) and those with immunocompromising conditions. The worldwide population aged 65 years and older is increasing, and the total number of aged individuals will outnumber those younger than 65 years by the year 2050. Aging is associated with a decline in immune function and chronic activation of inflammation that contributes to enhanced viral susceptibility and reduced responses to vaccination. Here we briefly review the pathogenicity of the virus, epidemiology and clinical response, and the underlying mechanisms of human aging in improving vaccination. We review current methods to improve vaccination in the older adults using novel vaccine platforms and adjuvant systems. We conclude by summarizing the existing clinical trials for a SARS-CoV-2 vaccine and discussing how to address the unique challenges for vaccine development presented with an aging immune system.
Search related documents:
Co phrase search for related documents- action mechanism and adaptive immune response: 1, 2, 3
- action mechanism and adaptive immune system: 1
- action mechanism and adaptive immunity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- action mechanism and adaptive innate: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- action mechanism and adaptive response: 1, 2, 3
- action mechanism and adaptor protein: 1
- action mechanism and adenosine guanosine: 1, 2
- action mechanism and adenovirus vector: 1
- action mechanism and adjuvant development: 1
- action mechanism and adjuvant efficacy: 1
- action mechanism and adjuvant potent: 1, 2
- action mechanism and adjuvant section: 1
- action mechanism and adjuvant system: 1
- action mechanism and liver damage: 1, 2, 3, 4
- action mechanism and long history: 1, 2, 3, 4, 5
- action mechanism and low activation: 1
- action mechanism and low frequency: 1, 2
- action mechanism and lymphoid tissue: 1, 2
- action mechanism and macrophage function: 1
Co phrase search for related documents, hyperlinks ordered by date