Author: Lyudmila Kovalchuke; Eugene V. Mosharov; Oren A. Levy; Lloyd A. Greene
Title: Stress-induced phospho-ubiquitin formation causes parkin degradation Document date: 2018_12_5
ID: ceepyyxj_58
Snippet: An important implication of our finding that phospho-Ub is involved in parkin loss is that a parkin activator (phospho-Ub) appears to be intimately linked with parkin degradation. We observed this phenomenon across different models of cellular stress, suggesting that it is broadly generalizable. Therefore, it is possible that degradation is a cellular mechanism by which activated parkin is "turned off"......
Document: An important implication of our finding that phospho-Ub is involved in parkin loss is that a parkin activator (phospho-Ub) appears to be intimately linked with parkin degradation. We observed this phenomenon across different models of cellular stress, suggesting that it is broadly generalizable. Therefore, it is possible that degradation is a cellular mechanism by which activated parkin is "turned off".
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