Author: Anniina Vihervaara; Dig Bijay Mahat; Samu V. Himanen; Malin A.H. Blom; John T. Lis; Lea Sistonen
Title: Stress-Induced Transcriptional Memory Accelerates Promoter-Proximal Pause-Release and Decelerates Termination over Mitotic Divisions Document date: 2019_3_14
ID: i3owd6b0_12
Snippet: Consequently, PRO-seq provides genome-wide maps of transcribing Pol II complexes at genes 85! and enhancers, and identifies regulatory decisions at high fidelity and spatio-temporal resolution 86! (reviewed in Wissink et al., invited manuscript under review). As cell models, we used Mouse 87! Embryonic Fibroblasts (MEFs) and human K562 erythroleukemia cells that reprogram 88! transcription upon heat shock with highly similar mechanisms Vihervaara.....
Document: Consequently, PRO-seq provides genome-wide maps of transcribing Pol II complexes at genes 85! and enhancers, and identifies regulatory decisions at high fidelity and spatio-temporal resolution 86! (reviewed in Wissink et al., invited manuscript under review). As cell models, we used Mouse 87! Embryonic Fibroblasts (MEFs) and human K562 erythroleukemia cells that reprogram 88! transcription upon heat shock with highly similar mechanisms Vihervaara et 89! al., 2017) . We found that transcriptional reprogramming by heat shock is followed by precise 90! restoration of basal cell type-specific transcription program of genes and enhancers.
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