Selected article for: "antiviral drug and apo form"
Author: Wanchao Yin; Chunyou Mao; Xiaodong Luan; Dan-Dan Shen; Qingya Shen; Haixia Su; Xiaoxi Wang; Fulai Zhou; Wenfeng Zhao; Minqi Gao; Shenghai Chang; Yuan-Chao Xie; Guanghui Tian; He-Wei Jiang; Sheng-Ce Tao; Jingshan Shen; Yi Jiang; Hualiang Jiang; Yechun Xu; Shuyang Zhang; Yan Zhang; H. Eric Xu
Title: Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir
  • Document date: 2020_4_9
    • ID: 7v7pzclb_1
    Snippet: However, no structure of the SARS-CoV-2 RdRp in complex with an RNA template or with nucleotide inhibitors has been solved, creating a knowledge gap in our understanding of working mechanism of RdRp and hampering the ongoing drug discovery effort against this viral infection. To fill in the above knowledge gap, we determined two cryo-EM structures of the SARS-CoV-2 RdRp complex either in the apo form or in a complex with a template-primer RNA and.....
    Document: However, no structure of the SARS-CoV-2 RdRp in complex with an RNA template or with nucleotide inhibitors has been solved, creating a knowledge gap in our understanding of working mechanism of RdRp and hampering the ongoing drug discovery effort against this viral infection. To fill in the above knowledge gap, we determined two cryo-EM structures of the SARS-CoV-2 RdRp complex either in the apo form or in a complex with a template-primer RNA and the antiviral drug Remdesivir.

    Search related documents:
    Co phrase search for related documents
    • apo form and cryo em: 1, 2, 3
    • apo form and cryo em structure: 1
    • apo form and RNA template: 1, 2, 3, 4
    • apo form and SARS RdRp complex: 1, 2
    • apo form and SARS RdRp structure: 1, 2, 3, 4
    • apo form and template primer: 1, 2, 3
    • apo form and viral infection: 1, 2, 3
    • complex SARS RdRp structure and cryo em: 1
    • complex SARS RdRp structure and cryo em structure: 1
    • complex SARS RdRp structure and RNA template: 1
    • complex SARS RdRp structure and SARS RdRp complex: 1, 2, 3, 4
    • complex SARS RdRp structure and SARS RdRp complex cryo em structure: 1
    • complex SARS RdRp structure and SARS RdRp structure: 1, 2, 3, 4
    • complex SARS RdRp structure and template primer: 1
    • cryo em and drug discovery: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
    • cryo em and knowledge gap: 1, 2, 3, 4
    • cryo em and nucleotide inhibitor: 1
    • cryo em and RNA template: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • cryo em and SARS RdRp complex: 1, 2, 3, 4, 5