Selected article for: "complex structure and RBD complex"

Author: Renhong Yan; Yuanyuan Zhang; Yingying Guo; Lu Xia; Qiang Zhou
Title: Structural basis for the recognition of the 2019-nCoV by human ACE2
  • Document date: 2020_2_20
  • ID: elo7kfun_3
    Snippet: ACE2 has also been suggested to be the receptor for the 2019-nCoV (3, 4) . The ectodomain of the 2019-nCoV S protein was reported to bind to the PD of ACE2 with a Kd of ~ 15 nM, measured with surface plasmon resonance (SPR) (5) . Docking analysis based on our structure of the ACE2-B 0 AT1 complex suggests that RBD can access to the PD, which protrudes into the extracellular space, in the presence of B 0 AT1, indicating compatibility of all three .....
    Document: ACE2 has also been suggested to be the receptor for the 2019-nCoV (3, 4) . The ectodomain of the 2019-nCoV S protein was reported to bind to the PD of ACE2 with a Kd of ~ 15 nM, measured with surface plasmon resonance (SPR) (5) . Docking analysis based on our structure of the ACE2-B 0 AT1 complex suggests that RBD can access to the PD, which protrudes into the extracellular space, in the presence of B 0 AT1, indicating compatibility of all three proteins for ternary complex formation (1).

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